EMC 2016

Scientific Programme

Life Sciences (LS) sessions

LS1 Macromolecular assemblies, supra molecular assemblies (3 slots)

Description of the session

The aim of this session is to describe the architecture of macromolecular assemblies using the latest state-of-the-art imaging technologies including (cryo-) electron microscopy/tomography and super resolution approaches. This session is focused on isolated object rather then on the same object in its cellular context. Special focus will be made on high resolution imaging and structure determination but also on dynamic studies and different state separation.

Keywords: macromolecular assemblies; high resolution ; cryo-electron  microscopy; super resolution; Protein /DNA /RNA complex; Ribosome; transcription factor & polymerase; molecular membrane assembly (channels, respiratory complexes); molecular cell assembly (Light harvesting complex, nuclear pore complexes etc..); eukaryotic, bacterial and viral nano-machines; Virus particles; ESCRT machinery; clathrin; innate immune response assemblies.

Co-Chairs


Guy SCHOEHN

Bettina BOETTCHER

Karen DAVIES
Grenoble, FR Edinburgh, UK Frankfurt, DE

Invited speakers

  • Yaser HASHEM (IBMC Strasbourg, FR)
  • Paula DA FONSECA (MRC Cambridge, UK)
  • Julian VON DER ECKEN (MPI Dortmund, DE)
  • Friedrich FOERSTER (MPI Martinsried, DE)

 


LS2 Cell organisation and dynamics (4 slots)

Description of the session

This session will focus on the imaging developments, which improve the knowledge of cell shape, its dynamic change during motility and differentiation, interactions with and development of proper responses to cellular microenvironments, as well as intracellular organisation and trafficking. Exciting recent research using novel optical configurations to track such cell dynamics should be covered.

Keywords: inter-and intracellular signalling dynamics. Cellular transport and dynamics; morphogenesis of cell compartments; tracking drug pathways and their targets; cytoskeleton, actin, microtubules, kinesin, septins; cell adhesion; cell migration; cell division; nucleus organisation.

Co-Chairs 


Chris HAWES

Isabelle ARNAL

Eija JOKITALO
Oxford, UK Grenoble, FR Helsinki, FI

Invited speakers
 

  • Thomas MULLER-REICHERT (university of Dresden, DE)  
  • Anja GEITMANN,  (Univ of montreal, CA)
  • Olivier HAMANT,  (ENS Lyon FR)
  • Lukas C. KAPITEIN (Utrecht, NL)
  • Eija JOKITALO (University of Helsinki, FI)

LS3 Cell functional exploration (2 slots)

Description of the session

Cells are complex machineries, which maintain their functional states and commit to cellular decisions based on external cues. Mapping biochemical pathways in space and time is crucial in order to explore and evaluate distinct cell functions. This session will report on novel developments and applications of biochemical imaging tools (including new fluorescent and electron microscopy probes, biosensors, optogenetics, and photoswitchable proteins).

Keywords: Metabolism imaging; Photoswitchable proteins; Photomanipulation; Fluorescent probes and Biosensors; Probes for electron or correlative light-electron microscopy; Quantum dots; Nanoparticle transducers; Optogenetics; Fluorescence polarization and quench body; Functionalized enzymes; Artificial metalloenzyme and functionalized membranes; Stimuli responsive molecules; Biological detection by optical sensing of molecular oxygen (O2), etc; Engineering bacterial phytochrome..

Co-Chairs
 


Franck RIQUET

Judith KLUMPERMAN
Lille, FR Utrecht, NL

Invited speakers

  • Ben GIEPMANS (University of Groningen, NL)
  • T.W.J. GADELLA Jr. (LCAM, Amsterdam, NL)
  • Sylvia GIORDANI (IIT, Genova, IT)

     

LS4 Membrane Interaction (1 slot)

Description of the session

The aim of the membrane interaction session is to show how new technologies in the field of microscopy have helped the current research on how lipids and proteins interact in membrane related cellular processes. In particular, a selection of new techniques in cryo-electron microscopy, high-resolution photonic microscopy or atomic force microscopy will be presented in examples where they were crucial for the understanding of protein-membrane and lipid-lipid interactions.

Co-Chairs
 


Aurélien ROUX

Hans HEBERT
Geneva, CH Huddinge, SE

Invited speakers

  • Thomas WALZ (Rockefeller University, New York, USA)
  • Didier MARGUET (Ciml Marseille, FR)
  • Christian EGGELING (Univ. of Oxford, UK)

 


LS5 Extra-cellular matrix (2 slots)

Description of the session

The extracellular matrix (ECM) consists of a complex mixture of cell-secreted macromolecules which together provide structural and biochemical support to tissues. This session provides an overview of different state-of-the art high-resolution imaging techniques, including optical super-resolution microscopy, atomic force microscopy, and electron microscopy, to study the structure and mechanics of different ECM components. When used in combination, these imaging techniques often provide important complementary information about ECM structure and function.

Keywords: extracellular matrix, collagen, fibronectin, elasticity, AFM, dSTORM, EM.

Co-Chairs 


Herman HÖFTE

Clemens M. FRANZ
Versailles, FR Karlsruhe, DE


Invited speakers

  • Daniel COSGROVE (Penn State, USA)
  • Marie-Claire SCHANNE-KLEIN (Paris, FR)

LS6 Host-pathogen Interactions  (2 slots)

Description of the session

This session 'Host-pathogen interaction' is devoted to the pathogen structure and analysis of dynamic interactions with host cells in the course of the of the pathogen. It will bring together leading imaging methods and the most advanced application with the aim of capturing the dynamics of host-pathogen interactions. This will span the whole range from imaging of whole cellular bacterial and viral organisms to quasi-atomic resolution description of pathogen and interactions with host components. The session will highlight new paradigms in host-pathogen interaction including insights into macromolecular machineries involved at different steps of the host-pathogen ‘life cycles’ including entry, replication, assembly, exit and spreading.

Keywords: virology; bacteriology; eukaryotic pathogens; parasitology; symbiosis; biofilms.

Co-Chairs


Ilaria FERLENGHI

Olivier LAMBERT

Kay GRUNEWALD
Sienna, IT Bordeaux, FR Oxford, GB

Invited speakers

  • Irina GUTSCHE (IBS Grenoble, FR)
  • Ana J. PEREZ  (Alba synchrotron, Barcelona, ES)
  • Misha KUDRYASHEV (MPI Frankfurt, DE)

     

LS7 Organism development and imaging (2 slots)

Description of the session

The LS7 session deals with organism development and imaging, on how to image and track over time at high resolution the development and growth of an organism. Understanding the mechanisms regulating the spatial and temporal control of gene expression or cell reorganisation during morphogenesis, organogenesis, regeneration, cell differentiation or apoptosis. 

Keywords: Developmental biology; model organisms; 4D microscopy; Super resolution; CLEM..

Co-Chairs 


Cristina PUJADES

Grégoire MICHAUX
Barcelona, ES Rennes, FR

Invited speakers

  • Claire WYART (ICM-UPMC, Paris, FR)
  • Scott FRASER (University of Southern California (USC), USA)
  • Jacky G.GOETZ (INSERM, Strasbourg, FR)



LS8 Human health and disease (1 slot)

Description of the session

Advance in the emerging field from intravital imaging to nanoscopy and its potential to reveal the dynamic processes in macromolecules, cells and tissues that could lead to discoveries in the detection, diagnosis and treatment of disease. Emphasis on the imaging of cancer, immune system, and neurodegenerative diseases.Keywords: intravital microscopy, 3D cryo-EM, visualizing molecular machines in action, cancer cell migration, immune defense,  neuro degeneration, drug targets…

Co-Chairs


Peter PETERS

Danijela VIGNJEVIC
Maastricht, NL Paris, FR

Invited speakers

  • Jacco VAN RHEENEN (Hubrecht Institute, Utrecht, NL)
  • Vicki GOLD (MPI Frankfurt, DE)
  • Hans HERBERT (Karolinska Institutet, Huddinge, SW)

 



LS9 Societal challenges and environment (1 slot)

Interdisciplinary session, common between life and material science

Description of the session

Besides its contribution to occurrence of new technologies development and new chemical industry products , a large spectrum of microscopy and imaging approaches is currently developed to reinforce the scrutiny, monitoring and assessment of ecological risk on various biological processes. For instance: impact of nanoparticles on living systems, biogeochemistry of metals in plants , pollution diagnostics and ecological risk assessment, regenerative medicine,  building diagnostic represent some application fields of Microscopy. This session will cover the continuous increase in the use of   Microscopy and Imaging  in medical,  industrial, societal or environmental biosafety issues  including sustainable developments.

Keywords: nanomaterials;  nanoparticles; pollution sensors;  medical or agricultural diagnostics,  drug delivery, thermal imaging, biodiversity, etc…

Co-Chairs: 

Béatrice SATIAT-JEUNEMAITRE

Kesara ANAMTHAWAT-JONSSON

Gif-Sur-Yvette, FR

Reykjavík, IC

Invited speakers:

  • Urszula STACHEWICZ (University of Science and Technology, Krakow, PO)
  • Marie-Pierre ISAURE (IPREM-UMR 5254/ LCABIE, Universite de Pau et des Pays de l'Adour, FR)